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Modifications of the proteins play key roles in controlling protein activity and hence cell function. This is mainly due to their ability to rapidly and reversibly change the behavior of the modified protein. These modifications regulate the localization of their substrates in the cell, their interactions with partner molecules such as proteins or DNA, their biological/enzymatic activity as well as their stability. Modification by ubiquitin is unusual in that the modifier itself is a small protein. A number of ubiquitin-like modifications have been described and, among these, modification by SUMO (Small Ubiquitin-like Modifier) is one of the most extensively studied.
Learn what SUMO (Small Ubiquitin-like Modifier) can do in cancer. Open the download file.
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SUMO in cancer
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