LA7 - Proteins In Balance: Muscle Development As An Example (»Add to Infobox)

Hoppe Thorsten, Professor

Thorsten Hoppe's Group

Thomas Löwe and Thorsten Hoppe Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) at the Institute for Genetics, University of Cologne, Germany Folding and stability of all cellular proteins (the proteome) is essential for cells and organisms throughout their lifetime. To adjust protein biogenesis to the demands of growth, differentiation, environmental stress and ageing, all cells possess a highly complex quality control network that balances synthesis, folding, translocation, assembly/disassembly, and turnover of proteins. The stability of the proteome (proteostasis) is challenged by exposure to proteotoxic environmental conditions, oxidant-induced covalent modifications, inherited polymorphisms, and misfolding.

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Hoppe Thorsten, Professor (Principal Investigator / Thorsten Hoppe's Group)

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