Christel Brou, Associate Professor (»Add to Infobox)

Researcher Alain Israël's Group Academic: Institut Pasteur, Paris Phone:  +33 1 40 61 30 41 Email:  christel.broupasteur.fr

Notch group General description: We are studying the molecular mechanisms underlying Notch signaling pathway : how the level of the Notch receptor is maintained at the cell membrane, how the signal is transduced, and finally how it is downregulated. All these processes involve ubiquitination and de-ubiquitination events, and various E3 ubiquitin ligases have been suggested to be involved : we study their relationship with Notch, by examining their interactions, their subcellular localisation, and the effects of modifying their expression level. We also try to correlate the type of ubiquitin chains formed on their targets and the fate of the molecules, e.g. proteasomal or lysosomal degradation, or other proteolytic cleavage leading to Notch activation. Through the use of a siRNA library allowing to knock-down most of the existing deubiquitinases (see R Bernards’ group), we will identify and study those which are involved in Notch signaling. Role in RUBICON: Coordinator of the Notch group

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