Frauke Melchior (»Add to Infobox)

Principal Investigator Frauke Melchior's Group Academic: Ruprecht-Karls-Universität Heidelberg Phone:  +49 (0)6221 54 6804 Fax:  +49 (0)6221 54 5893 Email:  f.melchiorzmbh.uni-heidelberg.de

Links: Frauke Melchior's Laboratory The Cellular Networks Homepage General description: Research in our group centers around posttranslational modification with small ubiquitin-related proteins of the SUMO family. Like ubiquitin, these proteins can be covalently and reversibly linked to other proteins. Attachment of SUMO does not lead to degradation, and instead serves to regulate protein-protein interactions, subcellular localization, enzymatic activity, and in some cases protects proteins from ubiquitin-dependent degradation. Projects in the lab aim to understand mechanism, regulation and function of SUMOylation. We are especially interested in the connection between SUMOylation and nucleocytoplasmic transport, the function and regulation of the SUMO model target RanGAP1, and links between SUMO- and ubiquitin-conjugation pathways. Role in RUBICON: Head of a research group, member of the executive committee, involved in research and training activities.

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