Klaus Schwamborn (»Add to Infobox)

Principal Investigator Pepscan SME: Pepscan systems BV Phone:  +31-320-225300 Fax:  +31-320-225301 Email:  k.schwambornpepscan.com

General description: Several sequence motifs for ubiquitin or SUMO-dependent destruction have been defined, but their precise structural aspects are often not yet understood. It will be essential to study the three-dimensional context of the degrons, as well as the specific SUMO-target sites to understand their specific roles, to identify them better and to provide a template for prediction in novel targets. For these studies good understanding of their target specificities is important. In order to delineate the sumoylation site, we will synthesize and screen peptides with candidate sumoylation sites within different secondary structural setting (helix, sheet), different location within the secondary structure and different neighbouring residues to in order to describe the primary sequence motif and structural motif of the sumoylaiton site.

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