Jacob Seeler (»Add to Infobox)

Researcher (Chargé de Recherche) Anne Dejean's Group Academic: Institut Pasteur, Paris Phone:  +33 1 45 68 80 86 Email:  seelerpasteur.fr

Nuclear Organization and Oncogenesis INSERM U579 General description: Higher-order nuclear architecture, PML/SP100 nuclear bodies, sumoylation and DNA repair, telomere and contromere structure and dynamics, transcriptional repression mechanisms via histone and DNA modifications. Role in RUBICON: Comparative approach (fission yeast/mammalian systems): genetics and biochemistry of sumoylation vis-à-vis genomic integrity and transcriptional silencing. Search for SUMO E3 ligase cofactors via yeast two hybrid and biochemical approaches.