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Publications from RUBICON partners
2008
1. - Rolén B, Freda E, Xie J, Pfirmann T, Frisan T and Masucci MG. 2008. The ubiquitin C-terminal hydrolase UCH1-L1 regulates B-cell proliferation and integrin activation. J Cell Mol Med. In press
2. - Sompallae R, Gastaldello S, Hildebrand S, Zinin N, Hassink G, Lindsten K, Haas J, Persson B, Masucci MG. 2008. Epstein-Barr virus encodes three bona fide ubiquitin-specific proteases. J Virol. 82:10477-86
3. - Belgareh-Touzé, N, Léon, S., Erpapazoglou, Z., Stawiecka, M., Urban-Grimal, D. and Haguenauer-Tsapis, R. (2008) Versatile role of the yeast ubiquitin ligase Rsp5p in intracellular trafficking. Biochem. Soc. Trans. 36:791-6
4. - Bedford L, Hay D, Devoy A, Paine S, Powe DG, Seth R, Gray T, Topham I, Fone K, Rezvani N, Mee M, Soane T, Layfield R, Sheppard PW, Ebendal T, Usoskin D, Lowe J, Mayer RJ. 2008. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies J Neurosci. 28:8189-98
5. - Erpapazoglou Z, Froissard M, Nondier I, Lesuisse E, Haguenauer-Tsapis R, Belgareh-Touzé N. 2008. Substrate- and Ubiquitin-Dependent Trafficking of the Yeast Siderophore Transporter Sit1. Traffic, 9:1372-91
6. - Kornitzer, D., and Ciechanover, A. (2008). Proteasomes/Ubiquitination. In: Handbook of Cell Signalling, 2nd ed. (Ralph A. Bradshaw, and Edward A. Dennis, eds.). Elsevier Science, San Diego, California, USA, and Academic Press.
7. - Navon, A., and Ciechanover, A. (2008) Ubiquitin-Proteasome Pathway. In: Wiley Encyclopedia of Biological Chemistry. John Wiley and Sons, Inc., USA.
8. - Mayer, R.J., Ciechanover, A., and Rechsteiner, M. (2008) Protein Degradation Handbook, Volume 4 (R.J. Mayer, A. Ciechanover, and M. Rechsteiner, Eds.). Volume 4. Wiley-VCH, Weinheim, Germany. pp. I-XV, 1-242
9. - Matic I, Macek B, Hilger M, Walther T, Mann M. (2008) Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution. J Proteome Res. 7:4050-7
10. - Sigismund S., Argenzio E., Tosoni D., Cavallaro E., Polo S. and Di Fiore P.P. (2008) Clathrin-mediated internalization is essential for sustained EGFR signalling but dispensable for degradation. Dev Cell. 15:209-19
11. - Heuss SF, Ndiaye-Lobry D, Six EM, Israël A, Logeat F. 2008. The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. Proc Natl Acad Sci U S A. 105:11212-7
12. - Knipscheer, P, Flotho A., Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK and Pichler A., (2008) Ubc9 sumoylation regulates SUMO target discrimination. Mol. Cell. 31:371-82
13. - Chastagner P, Israël A, Brou C. 2008. AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS ONE. 3:e2735
14. - Schimmel J, Larsen KM, Matic I, van Hagen M, Cox J, Mann M, Andersen JS, Vertegaal AC. (2008) The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle. Mol Cell Proteomics. In press
15. - Molinier J, Lechner E, Dumbliauskas E, Genschik P., 2008, Regulation and role of Arabidopsis CUL4-DDB1A-DDB2 in maintaining genome integrity upon UV stress. PLos Genet. 4:e1000093
16. - Kohlmann, S., Schäfer, A. and D.H. Wolf, (2008) Ubiquitin Ligase Hul5 Is Required for fragment-specific Substrate Degradation in Endoplasmic Reticulum-associated Degradation. J. Biol. Chem. 283:16374-83
17. - Franch-Marro X, Wendler F, Maurice MM and Vincent JP (2008) In vivo role of lipid adducts on Wingless. J Cell Sci. 121:1587-92
18. - Pohl., C. and Jentsch, S. (2008). Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. Cell 132:832-845
19. - Xirodimas DP, Sundqvist A, Nakamura A, Shen L, Botting C, Hay RT. (2008) Ribosomal proteins are targets for the NEDD8 pathway. EMBO Rep. 9:280-6
20. - Franch-Marro X, Wendler F, Guidato S, Griffith J, Baena-Lopez A, Itasaki N, Maurice MM, Vincent JP (2008) Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex. Nat Cell Biol. 10:170-77
21. - Martin, N., Schwamborn, K., Urlaub, H., Gan, B., Guan, J.L., Dejean, A. 2008. Spatial Interplay Between PIASy and FIP200 in the Regulation of Signal Transduction and Transcriptional Activity. Mol. Cell. Biol. 28:2771-81.
22. - Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palimony JJ and Hay RT. 2008. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat. Cell. Biol. 10:538-43
23. - Schwamborn, K., Knipscheer, P., van Dijk, E., van Dijk, WJ., Sixma, TK., Meloen, RH. and Langedijk JP. 2008. SUMO Assay with Peptide Arrays on Solid Support: Insights into SUMO Target Sites. J. Biochem. 144:39-49
24. - Meulmeester, E., Kunze, M., Hsiaoh, H.H., Urlaub, H., Melchior, F. 2008. Mechanism and consequences of paralog specific sumoylation of USP25. Mol. Cell. 30:610-9
25. - Meulmeester, E. and Melchior, F. 2008. SUMO. Nature 452:709-711
26. - Hutten, S., Flotho, A., Melchior, F. and Kehlenbach, R.H. 2008. The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. Mol. Biol. Cell. 19:2300-10
27. - Leon S., Erpapazoglou Z and Haguenauer-Tsapis R. Ear1p and Ssh4p Are New Adaptors of the Ubiquitin Ligase Rsp5p for Cargo Ubiquitylation and Sorting at Multivesicular Bodies. Mol Biol Cell. 19:2379-88
28. - Matic, I., M. van Hagen, J. Schimmel, B. Macek, S.C. Ogg, M.H. Tatham, R.T. Hay, A.I. Lamond, M. Mann, and A.C. Vertegaal. 2008. In Vivo Identification of Human Small Ubiquitin-like Modifier Polymerization Sites by High Accuracy Mass Spectrometry and an in Vitro to in Vivo Strategy. Mol Cell Proteomics. 7:132-44
29. - Cohen SX, Ben Jelloul M, Long F, Vagin A, Knipscheer P, Lebbink J, Sixma TK, Lamzin VS, Murshudov GN, Perrakis A. (2008) ARP/wARP and molecular replacement: the next generation. Acta Crystallogr D Biol Crystallogr. 64:49-60
30. - Colaluca, I.N., D. Tosoni, P. Nuciforo, F. Senic-Matuglia, V. Galimberti, G. Viale, S. Pece, and P.P. Di Fiore. 2008. NUMB controls p53 tumour suppressor activity. Nature. 451:76-80
2007
1. - Kessler BM, Fortunati E, Melis M, Pals CE, Clevers HC, Maurice MM (2007) Proteome changes induced by knock-down of the deubiquitinating enzyme HAUSP/USP7. J Proteome Res 6:4163-72
2. - Lobry C, Lopez T, Israël A, Weil R. 2007. Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10. Proc Natl Acad Sci U S A. 104:908-13
3. - van den Eijnden MJM, Strous GJ. 2007.Autocrine Growth Hormone: Effects on Growth Hormone Receptor Trafficking and Signaling: The effects of autocrine GH on the GHR. Mol. Endocrin 21:2832-46
4. - van Kerkhof P, Putters J, Strous GJ. 2007. The Ubiquitin Ligase SCF(betaTrCP) Regulates the Degradation of the Growth Hormone Receptor. J Biol Chem. 282:20475-83
5. Dada, L.A., L.C. Welch, G. Zhou, R. Ben-Saadon, A. Ciechanover, and J.I. Sznajder. 2007. Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia. Cell Signal. 19:1893-8
6. Geiss-Friedlander, R., and F. Melchior. 2007. Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol. 8:947-56
7. Herman-Bachinsky, Y., H.D. Ryoo, A. Ciechanover, and H. Gonen. 2007. Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Cell Death Differ. 14:861-71
8. Knipscheer, P., and T.K. Sixma. 2007. Protein-protein interactions regulate Ubl conjugation. Curr Opin Struct Biol. 17:665-73
9. Knipscheer, P., W.J. van Dijk, J.V. Olsen, M. Mann, and T.K. Sixma. 2007. Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. Embo J. 26:2797-807
10. Notenboom, V., R.G. Hibbert, S.E. van Rossum-Fikkert, J.V. Olsen, M. Mann, and T.K. Sixma. 2007. Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification. Nucleic Acids Res. 35:5819-30
11. Pelzer, C., I. Kassner, K. Matentzoglu, R.K. Singh, H.P. Wollscheid, M. Scheffner, G. Schmidtke, and M. Groettrup. 2007. UBE1L2, a novel E1 enzyme specific for ubiquitin. J Biol Chem. 282:23010-4
12. Shabek, N., K. Iwai, and A. Ciechanover. 2007. Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target. Biochem Biophys Res Commun. 363:425-31
13. Singh, R.K., S. Iyappan, and M. Scheffner. 2007. Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. J Biol Chem. 282:10901-7
14. Stankovic-Valentin, N., S. Deltour, J. Seeler, S. Pinte, G. Vergoten, C. Guerardel, A. Dejean, and D. Leprince. 2007. An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol Cell Biol. 27:2661-75
15. Tirard, M., O.F. Almeida, P. Hutzler, F. Melchior, and T.M. Michaelidis. 2007. Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor. Mol Cell Endocrinol. 268:20-9
16. Froissard, M., N. Belgareh-Touze, M. Dias, N. Buisson, J.M. Camadro, R. Haguenauer-Tsapis, and E. Lesuisse. 2007. Trafficking of Siderophore Transporters in Saccharomyces cerevisiae and Intracellular Fate of Ferrioxamine B Conjugates. Traffic. 8:1601-16
17. Scheffner, M., and O. Staub. 2007. HECT E3s and human disease. BMC Biochem. 8 Suppl 1:S6
18. Stawiecka-Mirota, M., W. Pokrzywa, J. Morvan, T. Zoladek, R. Haguenauer-Tsapis, D. Urban-Grimal, and P. Morsomme. 2007. Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylation. Traffic. 8:1280-96
19. Long, J., T.R. Gallagher, J.R. Cavey, P.W. Sheppard, S.H. Ralston, R. Layfield, and M.S. Searle. 2007. Ubiquitin recognition by the UBA domain of p62 involves a novel conformational switch. J Biol Chem 283:5427
20. Topffer, S., A. Muller-Schiffmann, K. Matentzoglu, M. Scheffner, and G. Steger. 2007. Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. J Gen Virol. 88:2956-65
21. Weiss, Y.G., Z. Bromberg, N. Raj, J. Raphael, P. Goloubinoff, Y. Ben-Neriah, and C.S. Deutschman. 2007. Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome. Crit Care Med. 35:2128-38
22. Bischof, O., and A. Dejean. 2007. SUMO is growing senescent. Cell Cycle. 6:677-81
23. Bortolamiol, D., M. Pazhouhandeh, K. Marrocco, P. Genschik, and V. Ziegler-Graff. 2007. The Polerovirus F box protein P0 targets ARGONAUTE1 to suppress RNA silencing. Curr Biol. 17:1615-21
24. Braun, S., and S. Jentsch. 2007. SM-protein-controlled ER-associated degradation discriminates between different SNAREs. EMBO Rep. 8:1176-82
25. - Carter, S., O. Bischof, A. Dejean, and K.H. Vousden. 2007. C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol. 9:428-35
26. Jentsch, S., and S. Rumpf. 2007. Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway? Trends Biochem Sci. 32:6-11
27. Moldovan, G.L., B. Pfander, and S. Jentsch. 2007. PCNA, the maestro of the replication fork. Cell. 129:665-79
28. Park, S.H., N. Bolender, F. Eisele, Z. Kostova, J. Takeuchi, P. Coffino, and D.H. Wolf. 2007. The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell. 18:153-65
29. Seeler, J.S., O. Bischof, K. Nacerddine, and A. Dejean. 2007. SUMO, the three Rs and cancer. Curr Top Microbiol Immunol. 313:49-71
30. Torres-Rosell, J., I. Sunjevaric, G. De Piccoli, M. Sacher, N. Eckert-Boulet, R. Reid, S. Jentsch, R. Rothstein, L. Aragon, and M. Lisby. 2007. The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus. Nat Cell Biol. 9:923-31
31. Tuvia, S., D. Taglicht, O. Erez, I. Alroy, I. Alchanati, V. Bicoviski, M. Dori-Bachash, D. Ben-Avraham, and Y. Reiss. 2007. The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp. J Cell Biol. 177:51-61
32. Woelk, T., S. Sigismund, L. Penengo, and S. Polo. 2007. The ubiquitination code: a signalling problem. Cell Div. 2:11
33. Xhemalce, B., E.M. Riising, P. Baumann, A. Dejean, B. Arcangioli, and J.S. Seeler. 2007. Role of SUMO in the dynamics of telomere maintenance in fission yeast. Proc Natl Acad Sci U S A. 104:893-8
2006
1. - Vinolo E, Sebban H, Chaffotte A, Israël A, Courtois G, Véron M, Agou F. 2006. A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation. J Biol Chem. 281:6334-48
2. - van den Eijnden MJM, Lahaye LL, Strous GJ. 2006. Disulfide bonds determine Growth Hormone Receptor folding, dimerisation and ligand binding. J Cell Science 119:3078-3086
3. - Hirsch, C., Gauss, R, and Sommer T. 2006. Coping with stress: cellular relaxation techniques. Trends Cell Biol. 16:657-63
4. - Bossis, G. and Melchior, F. (2006) SUMO: regulating the regulator. Cell Div. 1:13 (Review)
5. - Bossis, G. and Melchior, F. 2006. Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes. Mol. Cell 21:349-357
6. Ben-Saadon, R., D. Zaaroor, T. Ziv, and A. Ciechanover. 2006. The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity. Mol Cell. 24:701-11
7. Bosch-Comas, A., K. Lindsten, R. Gonzalez-Duarte, M.G. Masucci, and G. Marfany. 2006. The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. Cell Mol Life Sci. 63:723-34
8. Buchwald, G., P. van der Stoop, O. Weichenrieder, A. Perrakis, M. van Lohuizen, and T.K. Sixma. 2006. Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. Embo J. 25:2465-74.
9. Ciechanover, A. 2006. The ubiquitin proteolytic system: from an idea to the patient bed. Proc Am Thorac Soc. 3:21-31
10. Ciechanover, A. 2006. The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology. 66:S7-19
11. Cohen, S., S. Lahav-Baratz, and A. Ciechanover. 2006. Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105 proteolysis. Biochem Biophys Res Commun. 345:7-13
12. Jaffray, E.G., and R.T. Hay. 2006. Detection of modification by ubiquitin-like proteins. Methods. 38:35-8
13. Janssen, K., T.G. Hofmann, D.A. Jans, R.T. Hay, K. Schulze-Osthoff, and U. Fischer. 2006. Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies. Oncogene
14. Pazhouhandeh, M., M. Dieterle, K. Marrocco, E. Lechner, B. Berry, V. Brault, O. Hemmer, T. Kretsch, K.E. Richards, P. Genschik, and V. Ziegler-Graff. 2006. F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function. Proc Natl Acad Sci U S A. 103:1994-9
15. Reinstein, E., and A. Ciechanover. 2006. Narrative review: protein degradation and human diseases: the ubiquitin connection. Ann Intern Med. 145:676-84
16. Rolen, U., V. Kobzeva, N. Gasparjan, H. Ovaa, G. Winberg, F. Kisseljov, and M.G. Masucci. 2006. Carcinog. 45:260-9
17. Shen, L., M.H. Tatham, C. Dong, A. Zagorska, J.H. Naismith, and R.T. Hay. 2006. SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol. 13:1069-77
18. Shen, L.N., C. Dong, H. Liu, J.H. Naismith, and R.T. Hay. 2006. The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem J. 397:279-88
19. Vertegaal, A.C., J.S. Andersen, S.C. Ogg, R.T. Hay, M. Mann, and A.I. Lamond. 2006. Distinct and Overlapping Sets of SUMO-1 and SUMO-2 Target Proteins Revealed by Quantitative Proteomics. Mol Cell Proteomics. 5:2298-310
20. Weil, R., and A. Israel. 2006. Deciphering the pathway from the TCR to NF-kappaB. Cell Death Differ. 13:826-33
21. Israel, A. 2006. NF-kappaB activation: Nondegradative ubiquitination implicates NEMO. Trends Immunol. 27:395-7
22. Lee, J., J.H. Mo, K. Katakura, I. Alkalay, A.N. Rucker, Y.T. Liu, H.K. Lee, C. Shen, G. Cojocaru, S. Shenouda, M. Kagnoff, L. Eckmann, Y. Ben-Neriah, and E. Raz. 2006. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol. 8:1327-36
23. Woelk, T., B. Oldrini, E. Maspero, S. Confalonieri, E. Cavallaro, P.P. Di Fiore, and S. Polo. 2006. Molecular mechanisms of coupled monoubiquitination. Nat Cell Biol. 8:1246-54
24. Bischof, O., K. Schwamborn, N. Martin, A. Werner, C. Sustmann, R. Grosschedl, and A. Dejean. 2006. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol Cell. 22:783-94
25. Gauss, R., T. Sommer, and E. Jarosch. 2006. The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment. Embo J. 25:1827-35
26. Hoeller, D., N. Crosetto, B. Blagoev, C. Raiborg, R. Tikkanen, S. Wagner, K. Kowanetz, R. Breitling, M. Mann, H. Stenmark, and I. Dikic. 2006. Regulation of ubiquitin-binding proteins by monoubiquitination. In Nat Cell Biol. Vol. 8.163-9
27. Cavey, J.R., S.H. Ralston, P.W. Sheppard, B. Ciani, T.R. Gallagher, J.E. Long, M.S. Searle, and R. Layfield. 2006. Loss of Ubiquitin Binding Is a Unifying Mechanism by Which Mutations of SQSTM1 Cause Paget's Disease of Bone. Calcif Tissue Int. 78:271-277
28. Chastagner, P., A. Israel, and C. Brou. 2006. Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. EMBO Rep. 7:1147-53
29. Polo, S., and P.P. Di Fiore. 2006. Endocytosis conducts the cell signaling orchestra. Cell. 124:897-900
30. Penengo, L., M. Mapelli, A.G. Murachelli, S. Confalonieri, L. Magri, A. Musacchio, P.P. Di Fiore, S. Polo, and T.R. Schneider. 2006. Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell. 124:1183-95
31. Eisele, F., B. Braun, T. Pfirrmann, and D.H. Wolf. 2006. Mutants of the deubiquitinating enzyme Ubp14 decipher pathway diversity of ubiquitin-proteasome linked protein degradation. Biochem Biophys Res Commun. 350:329-33
32. Gauss, R., E. Jarosch, T. Sommer, and C. Hirsch. 2006. A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery. Nat Cell Biol. 8:849-54
33. Fernandez-Lloris, R., N. Osses, E. Jaffray, L.N. Shen, O.A. Vaughan, D. Girwood, R. Bartrons, J.L. Rosa, R.T. Hay, and F. Ventura. 2006. Repression of SOX6 transcriptional activity by SUMO modification. FEBS Lett. 580:1215-21
34. Hay, R.T. 2006. Role of ubiquitin-like proteins in transcriptional regulation. Ernst Schering Res Found Workshop:173-92
35. Arakawa, H., G.L. Moldovan, H. Saribasak, N.N. Saribasak, S. Jentsch, and J.M. Buerstedde. 2006. A role for PCNA ubiquitination in immunoglobulin hypermutation. PLoS Biol. 4:e366
36. Sacher, M., B. Pfander, C. Hoege, and S. Jentsch. 2006. Control of Rad52 recombination activity by double-strand break-induced SUMO modification. Nat Cell Biol. 8:1284-90
37. Moldovan, G.L., B. Pfander, and S. Jentsch. 2006. PCNA controls establishment of sister chromatid cohesion during S phase. Mol Cell. 23:723-32
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