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Publications from RUBICON partners
2011
1. Krumova, P., Meulmeester, E., Garrido, M., Tirard, M., Hsiao, H.S., Bossis, G., Urlaub, H., Zweckstetter, M., Kügler, S., Melchior, F., Bähr, M., Weishaupt, J.H. Sumoylation inhibits {alpha}-synuclein aggregation and toxicity. J Cell Biol. 2011 Jul 11; 194(1):49-60
2. Mishra, S.K., Ammon, T., Popowicz, G.M., Krajewski, M., Nagle, R.J., Ares, M., Holak, T.A., and Jentsch, S. (2011).Role of the ubiquitin-like protein Hub1 in splice site usage and alternative splicing. Nature 2011 May 25;474(7350):173-8.
3. Coppotelli G, Mughal N, Marescotti D, Masucci MG. High avidity binding to DNA protects ubiquitinated substrates from proteasomal degradation. J Biol Chem. 2011 Apr 6. [Epub ahead of print]
4. Luna-Vargas MP, Christodoulou E, Alfieri A, van Dijk WJ, Stadnik M, Hibbert RG, Sahtoe DD, Clerici M, Marco VD, Littler D, Celie PH, Sixma TK, Perrakis A. Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases. J Struct Biol. 2011 Mar 29. [Epub ahead of print]
5. Ziv I, Matiuhin Y, Kirkpatrick DS, Erpapazoglou Z, Leon S, Pantazopoulou M, Kim W, Gygi SP, Haguenauer-Tsapis R, Reis N, Glickman MH, Kleifeld O. A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Mol Cell Proteomics. 2011 Mar 22. [Epub ahead of print]
6. Hibbert RG, Huang A, Boelens R, Sixma TK. E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5590-5. Epub 2011 Mar 21
7. Luna-Vargas MP, Faesen AC, van Dijk WJ, Rape M, Fish A, Sixma TK. Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain. EMBO Rep. 2011 Apr 1;12(4):365-72. Epub 2011 Mar 18
8. - Maspero E, Mari S, Valentini E, Musacchio A, Fish A, Pasqualato S, Polo S. Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation. EMBO Rep. 2011 Apr 1;12(4):342-9. Epub 2011 Mar 11.
9. - de Bie, P. and Ciechanover, A. Ubiquitination of E3 Ligases: Self Regulation of the Ubiquitin System via Proteolytic and Non-Proteolytic Mechanisms. Cell Death Differ. 2011. Mar 4, [Epub ahead of print].
10. - Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, Hu MC, Chen DJ, Oren M, Shiloh Y. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell. 2011 Mar 4;41(5):529-42
11. - Heinen C, Acs K, Hoogstraten D, Dantuma NP. C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation. Nat Commun. 2011 Feb; 2:191
12. - Pazhouhandeh M, Molinier J, Berr A, Genschik P. MSI4/FVE interacts with CUL4-DDB1 and a PRC2-like complex to control epigenetic regulation of flowering time in Arabidopsis, Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3430-5. Epub 2011 Jan 31
13. - Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G,Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y. CKIα ablation highlights a critical role for p53 in invasiveness control. Nature. 2011 Feb 17;470(7334):409-13
14. - Kuhlbrodt K, Janiesch PC, Kevei É, Segref A, Barikbin R, Hoppe T. The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol. 2011 Mar;13(3):273-81. Epub 2011 Feb 13
15. - Putters J, da Silva Almeida AC, van Kerkhof P, van Rossum AG, Gracanin A, Strous GJ. Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. PLoS One. 2011 Feb 9; 6(2):e14676
16. - Segref A, Torres S, Hoppe T. A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans. Genetics. 2011 Apr;187(4):1235-40. Epub 2011 Feb 1
17. - Luise C, Capra M, Donzelli M, Mazzarol G, Jodice MG, Nuciforo P, Viale G, Di Fiore PP, Confalonieri S. An atlas of altered expression of deubiquitinating enzymes in human cancer. PLoS One. 2011 Jan 25; 6(1):e15891
18. - Argenzio E, Bange T, Oldrini B, Bianchi F, Peesari R, Mari S, Di Fiore PP, Mann M, Polo Proteomic snapshot of the EGF-induced ubiquitin network. Mol Syst Biol. 2011 Jan 18; 7:462.
19. - Dumbliauskas E, Lechner E, Jaciubek M, Berr A, Pazhouhandeh M, Alioua M, Cognat V, Brukhin V, Koncz C, Grossniklaus U, Molinier J, Genschik P. The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting. EMBO J. 2011 Feb 16;30(4):731-43. Epub 2011 Jan 14
20. - Moutty MC, Sakin V, Melchior F. Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme. Mol Biol Cell. 2011 Mar;22(5):652-60. Epub 2011 Jan 5
21. - Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S. Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1763-70. Epub 2011 Jan 5
22. - Kravtsova-Ivantsiv Y, Cohen S, Ciechanover A. Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursor. Adv Exp Med Biol. 2011; 691:95-106.
23. - van Kerkhof P, Westgeest M, Hassink G, Strous GJ. SCF(TrCP) acts in endosomal sorting of the GH receptor. Exp Cell Res. 2011 Apr 15;317(7):1071-82. Epub 2010 Dec 30
24. - Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R. TSPYL5 suppresses p53 levels and function by physical interaction with USP7. Nat Cell Biol. 2011 Jan;13(1):102-8. Epub 2010 Dec 19
25. - Putters J, Slotman JA, Gerlach JP, Strous GJ. Specificity, location and function of βTrCP isoforms and their splice variants. Cell Signal. 2011 Apr;23(4):641-7. Epub 2010 Dec 5
26. - Coombs, N, Sompallae R, Olbermann P, Gastaldello S, Göppel D, Masucci MG, Josenhans C.. Helicobacter pylori affects the cellular deubiquitinase USP7 and ubiquitin-regulated components TRAF6 and the oncoprotein p53. Int.J.Med Microbiol. 2011 Mar;301(3):213-24. Epub 2010 Dec 4
27. - Demarque MD, Nacerddine K, Neyret-Kahn H, Andrieux A, Danenberg E, Jouvion G, Bomme P, Hamard G, Romagnolo B, Terris B, Cumano A, Barker N, Clevers H, Dejean A. Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice. Gastroenterology. 2011 Jan; 140(1):286-96. Epub 2010 Oct 14
28. - Pece, S., Confalonieri, S., Romano, P., and Di Fiore, P. P. NUMB-ing down cancer by more than just a NOTCH. Biochimica et Biophysica Acta 2011 Jan; 1815(1):26-43. Epub 2010 Oct 16
2010
1. - Moretti J, Chastagner P, Gastaldello S, Heuss SF, Dirac AMG, Bernards R, Masucci M, Israël A and Brou C. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. PLoS Biology. 2010 Nov 23; 8(11):e1000545
2. - Shen D, Coleman J, Chan E, Nicholson TP, Dai L, Sheppard PW, Patton WF. Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Proteinm Accumulation Within Aggresomes and Inclusion Bodies. Cell Biochem Biophys. 2010 Dec 5. [Epub ahead of print]
3. - El Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H. Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin. Angew Chem Int Ed Engl. 2010 Dec 2; 49(52):10149-53
4. - Bassères E, Coppotelli G, Pfirrmann T, Andersen JB, Masucci MG, Frisan T. The ubiquitin C-terminal hydrolase UCH-L1 promotes bacterial invasion by altering the dynamics of the actin cytoskeleton. Cell Microbiol. 12(11):1622-33. doi: 10.1111/j.1462-5822.2010.01495.x. Nov
5. - Noutsou M, Duarte AM, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SG, Maurice MM. Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded. J Mol Biol. 2011 Jan 21;405(3):773-86. Epub 2010 Nov 16
6. - Hoppe T. Life and destruction: ubiquitin-mediated proteolysis in aging and longevity. F1000 Biol Rep. 2010 Nov 11;2:79
7. - Eger S, Scheffner M, Marx A, Rubini M. Synthesis of defined ubiquitin dimers. J Am Chem Soc. 2010 Nov 24;132(46):16337-9. Epub 2010 Oct 29.
8. - Buchberger, A., Bukau, B., Sommer, T. Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms. Mol Cell, 40(2):238-52 Oct 22;
9. - Iyappan S, Wollscheid HP, Rojas-Fernandez A, Marquardt A, Tang HC, Singh RK, Scheffner M (2010). Turning the RING domain protein MdmX into an active ubiquitin-protein ligase. J Biol Chem 285 (43):33065-72 Oct 22
10. - Stolz, A., Schweizer, R. Schäfer, A. and D.H. Wolf (2010) Dfm1 Forms Distinct Complexes with Cdc48 and the ER Ubiquitin Ligases and Is Required for ERAD, Traffic 11, 1363-1369 Oct
11. - Tauriello DVF and Maurice MM The various roles of ubiquitin in Wnt pathway regulation. Cell Cycle 9(18): 3700-3709 Sep
12. - de Bie P, Zaaroor-Regev D, and Ciechanover A. (2010).Regulation of the Polycomb protein RING1B ubiquitination by USP7.Biochem. Biophys. Res. Commun. 24:400(3):389-95 Aug 26
13. - Mehnert M, Sommer T, Jarosch E. ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum. Bioessays. 32(10):905-13 Aug 30
14. - Eisele, F., Schäfer, A. and D.H. Wolf Ubiquitylation In the ERAD Pathway in: Conjugation and Deconjugation of Ubiquitin Family Modifiers (ed. M. Groetrupp), Subcellular Biochemistry Vol. 54:136-148, Landes Bioscience Aug 11
15. - Bedford L, Paine S, Sheppard PW, Mayer RJ and Roelofs J. Assembly, structure and function of the 26S proteasome. Trends Cell Biol. 20:391-401´. Jul
16. - Shanmugham A, Fish A, Luna-Vargas MP, Faesen AC, El Oualid F, Sixma TK, Ovaa H. Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes. J Am Chem Soc. 132(26):8834-5 Jul 7
17. - Bagola K, Mehnert M, Jarosch E, Sommer T. Protein dislocation from the ER. Biochim Biophys Acta. Jul 3. Epub ahead of print
18. - Eichinger, C. S. and Jentsch, S. Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1. Proc Natl Acad Sci U S A. 107(25):11370-5 Jun 22
19. - Parnas O, Zipin-Roitman A, Pfander B, Liefshitz B, Mazor Y, Ben-Aroya S, Jentsch S, Kupiec M. Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA. EMBO J. 2010 Aug 4;29(15):2611-22. Epub 2010 Jun 22
20. - Xirodimas DP, Scheffner M. Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53. Subcell Biochem. 2010; 54:116-35
21. - Dirac AM and Bernards R. The deubiquitinating enzyme USP26 is a regulator of Androgen Receptor Signaling. Mol Cancer Res. 8(6):844-54 Jun
22. - Aichem A, Pelzer C, Lukasiak S, Kalveram B, Sheppard PW, Rankin J, Schmidtke G and Groettrup M. USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis. Nat. Comm. 1:1-10 May
23. - Salomons FA, Acs K, Dantuma NP. Illuminating the ubiquitin/proteasome system. Exp. Cell Res. 316:1289-1295 May
24. - Frosi Y, Anastasi S, Ballarò C, Varsano G, Castellani L, Maspero E, Polo S, Alemà S, Segatto O. A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. J Cell Biol. 2010 May 3;189(3):557-71. Epub 2010 Apr 26
25. Ribet D, Hamon M, Gouin E, Nahori MA, Impens F, Kahn H, Gevaert K, Vandekerckhove J, Dejean A. and Cossart P. Listeria monocytogenes impairs SUMOylation for efficient infection. Nature. 464:1192-5 Apr 22
26. Gastaldello S, Hildebrand S, Faridani O, Callegari S, Palmkvist M, Di Guglielmo CX, Masucci MG. A deneddylase encoded by Epstein Barr virus promotes viral DNA replication by regulating the activity of cullin-RING-ligases. Nat. Cell Biol. 12:351-361 Apr
27. Lauwers E, Erpapazoglou Z, Haguenauer-Tsapis R and André B. The ubiquitin code of yeast permeases. Trends in Cell Biology. 20:196-204 Apr
28. - Kashuba, E., Yurchenko, M., Yenamandra, S.P., Snopok, B., Szekely, L., Bercovich, B., Ciechanover, A., and Klein, G. Epstein-Barr Virus-Encoded EBNA-5 Forms Trimolecular Protein Complexes with MDM2 and p53 and inhibits the transactivating function of p53. Int J Cancer. Epub ahead of print Apr 19
29. - Heinen C, Garner TP, Long J, Böttcher C, Ralston SH, Cavey JR, Searle MS, Layfield R and Dantuma NP. Mutant p62/SQSTM1 UBA domains linked to Paget’s disease of bone differ in their abilities to function as stabilization signals. FEBS Lett. 584(8):1585-90 2010 Apr 16
30. - Karras GI, Jentsch S. The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase. Cell. 2010 Apr 16; 141(2):255-67
31. - Zaaroor-Regev, D., de Bie, P., Scheffner, M., Noy, T., Shemer, R., Heled, M., Stein, I., Pikarsky, E., and Ciechanover, A. (2010). Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proc Natl Acad Sci U S A. 107(15):6788-93 Apr 13
32. - Splinter D, Tanenbaum ME, Lindqvist A, Jaarsma D, Flotho A, Yu KL, Grigoriev I, Engelsma D, Haasdijk ED, Keijzer N, Demmers J, Fornerod M, Melchior F, Hoogenraad CC, Medema RH, Akhmanova A. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol. 2010 Apr 6; 8(4):e1000350
33. - Tauriello DVF, Haegebarth A, Kuper I, Canninga-van Dijk M, Edelmann MJ, Henraat M, Kessler, BM, Clevers H, Maurice MM. Loss of the tumor suppressor CYLD enhances Wnt/b-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell 37: 607-619 Mar
34. Kanarek N, Horwitz E, Mayan I, Leshets M, Cojocaru G, Davis M, Tsuberi BZ, Pikarsky E, Pagano M and Ben-Neriah Y. Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion. Genes Dev. 5:470-7 Mar 1
35. Kanarek N, London N, Schueler-Furman O and Ben-Neriah Y. Ubiquitination and degradation of the inhibitors of NF-κB. Cold Spring Harb Perspect Biol. 2:a000166 Feb
36. - Stolz, A. and D.H. Wolf (2010) Endoplasmic reticulum associated protein degradation: A chaperone assisted journey to hell, Biochim Biophys Acta 1803, 694-705 Feb 25
37. - Gluschnaider U, Hidas G, Cojocaru G, Yutkin V, Ben-Neriah Y, Pikarsky E. beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor. PLoS One 5:e9060 Feb 5
38. - Scita, G., and Di Fiore, P. P. The endocytic matrix. Nature 463, 464-473 Jan 28
39. - Dantuma NP and Lindsten K. Stressing the ubiquitin/proteasome system. Cardiovascul. Res. 85:263-271 Jan
40. Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM, Dejean A. miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci U S A. 107(1):264-9 Jan
41. Janer A, Werner A, Takahashi-Fujigasaki J, Daret A, Fujigasaki H, Takada K, Duyckaerts C, Brice A, Dejean A, Sittler A. . SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7. Hum. Mol. Genet, 19:181-195 Jan
42. Grubisha O, Kaminska M, Duquerroy S, Fontan E, Cordier F, Haouz A, Raynal B, Chiaravalli J, Delepierre M, Israël A, Véron M, Agou F. DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding. J Mol Biol, 395:89-104 Jan 8
43. Pece S, Tosoni D, Confalonieri S, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, and Di Fiore PP. Molecular and biological heterogeneity of breast cancers correlates with their cancer stem cell content. Cell. 140(1):62-73 Jan 8
2009
1. - Beskow A, Grimberg KB, Bott LC, Salomons FA, Dantuma NP and Young P. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. J. Mol. Biol. 394:732-746
2. Jentsch S and Siepe D. Pin1, a novel switch in the ubiquitin pathway. Cell Cycle 8:s3800-3801
3. Schäfer, A. and Wolf, D.H. Sec61 is part of the endoplasmic reticulum degradation machinery EMBO J. 28:2874-2884
4. Laplantine E, Fontan E, Chiaravalli J, Lopez T, Lakisic G, Véron M, Agou F, Israël A. NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. , EMBO J. 28(19):2885-95
5. Horn, S.C., Hanna, J., Hirsch, C., Volkwein, C., Schütz, A., Heinemann, U., Sommer, T., and Jarosch, E. Usa1 functions as a scaffold of the HRD-ubiquitin ligase. Mol. Cell 36:782-793
6. Gruhne B, Kamranvar SA, Masucci MG, Sompallae R. EBV and genomic instability -a new look at the role of the virus in the pathogenesis of Burkitt's lymphoma. Semin Cancer Biol. 19:394-400
7. Tatham MH, Rodriguez MS, Xirodimas DP, Hay RT. Detection of protein SUMOylation in vivo. Nature Protocols. 4(9):1363-71
8. Martin, N., Schwamborn, K., Schreiber, V., Werner, A., Guillier, C., Zhang, X-D., Bischof, O., Seeler, J., and Dejean, A. PARP1 transcriptional activity is regulated by sumoylation upon heat shock. EMBO J, 28:3534-3548
9. Navon, A., and Ciechanover, A. The 26S Proteasome - From Basic Mechanisms to Drug Target. J. Biol. Chem. 284:33713-33718
10. Cohen, S., Ciechanover, A. Kravtsova-Ivantsiv, Y., Lapid, D., and Lahav-Baratz, S. ABIN-1 negatively regulates NF-kB by inhibiting processing of the p105 precursor. Biochem. Biophys. Res. Commun. 389:205-10
11. Tatham MH, Hay RT. FRET-based in vitro assays for the analysis of SUMO protease activities. Methods Mol Biol. 497:253-68
12. Shen LN, Geoffroy MC, Jaffray EG, Hay RT. Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem J. 421(2):223-30
13. Geoffroy MC, Hay RT. An additional role for SUMO in ubiquitin-mediated proteolysis. Nat Rev Mol Cell Biol. 10(8):564-8
14. Acconcia F, Sigismund S, Polo S. Ubiquitin in trafficking: the network at work. Exp Cell Res. 315(9):1610-8
15. Jung JE, Wollscheid HP, Marquardt A, Manea M, Scheffner M, Przybylski M. Functional ubiquitin conjugates with lysine-epsilon-amino-specific linkage by thioether ligation of cysteinyl-ubiquitin peptide building blocks. Bioconjug Chem. 20(6):1152-62
16. Alberts SM, Sonntag C, Schäfer A, Wolf DH. Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem. 284(24):16082-9
17. Votteler J, Iavnilovitch E, Fingrut O, Shemesh V, Taglicht D, Erez O, Sörgel S, Walther T, Bannert N, Schubert U, Reiss Y. Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release. BMC Biochem. 10:12
18. Siepe D, Entsch S. Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation. Nat Cell Biol. 11(8):967-72
19. Hirsch C, Gauss R, Horn SC, Neuber O, Sommer T. The ubiquitylation machinery of the endoplasmic reticulum. Nature. 458(7237):453-60
20. Hassink GC, Zhao B, Sompallae R, Altun M, Gastaldello S, Zinin NV, Masucci MG, Lindsten K. The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates. EMBO Rep. 10(7):755-61
21. Di Fiore PP. Endocytosis, signaling and cancer, much more than meets the eye. Preface. Mol Oncol. 3(4):273-9
22. Confalonieri S, Quarto M, Goisis G, Nuciforo P, Donzelli M, Jodice G, Pelosi G, Viale G, Pece S, Di Fiore PP. Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor. Oncogene. 28(33):2959-68
23. Bergink S, Jentsch S. Principles of ubiquitin and SUMO modifications in DNA repair. Nature. 458(7237):461-7
24. Segref A, Hoppe T. Think locally: control of ubiquitin-dependent protein degradation in neurons. EMBO Rep. 10(1):44-50
25. Paiva S, Vieira N, Nondier I, Haguenauer-Tsapis R, Casal M, Urban-Grimal D. Glucose-induced ubiquitylation and endocytosis of the yeast Jen1 transporter: role of lysine 63-linked ubiquitin chains. J Biol Chem. 284(29):19228-36
26. Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang YH, Muller S, Scheffner M, Haupt S, Haupt Y. E6AP promotes the degradation of the PML tumor suppressor. Cell Death Differ. 16:1156-66
27. Journo C, Filipe J, About F, Chevalier SA, Afonso PV, Brady JN, Flynn D, Tangy F, Israël A, Vidalain PO, Mahieux R, Weil R. NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein. PLoS Pathog. 5:e1000521
28. Paine S, Bedford L, Thorpe JR, Mayer RJ, Cavey JR, Bajaj N, Sheppard PW, Lowe J, Layfield R. Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration. Neurosci Lett. 460:205-8
29. Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT. System-wide changes to SUMO modifications in response to heat shock. Sci Signal. 2(72):ra24
30. Geiss-Friedlander R, Parmentier N, Moeller U, Urlaub H, Van den Eynde BJ, Melchior F. The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides. J Biol Chem. 284(40):27211-9
31. Shabek N, Herman-Bachinsky Y, Ciechanover A. Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation. Proc Natl Acad Sci U S A. 106:11907-12
32. Marteijn JA, van der Meer LT, Smit JJ, Noordermeer SM, Wissink W, Jansen P, Swarts HG, Hibbert RG, de Witte T, Sixma TK, Jansen JH, van der Reijden BA. The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains. Leukemia. 23:1480-9
33. Kravtsova-Ivantsiv Y, Cohen S, Ciechanover A. Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor. Mol Cell. 33:496-504
34. Hsiao HH, Meulmeester E, Frank BT, Melchior F, Urlaub H. "ChopNspice", a mass-spectrometric approach that allows identification of endogenous SUMO-conjugated peptides. Mol Cell Proteomics. 8(12):2664-75
35. Hibbert RG, Mattiroli F, Sixma TK. Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair. DNA Repair (Amst). 8:525-35
36. Gusti A, Baumberger N, Nowack M, Pusch S, Eisler H, Potuschak T, De Veylder L, Schnittger A, Genschik P. The Arabidopsis thaliana F-box protein FBL17 is essential for progression through the second mitosis during pollen development. PLoS One. 4:e4780
37. Deichsel A, Mouysset J, Hoppe T. The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication. Cell Cycle. 8:185-90
38. Luijsterburg, M.S., C. Dinant, H. Lans, E. Wiernasz, S. Lagerwerf, D.O. Warmerdam, M. Lindh, M.C. Brink, J.W. Dobrucki, J.A. Aten, M.I. Fousteri, G. Jansen, N.P. Dantuma, W. Vermeulen, L.H.F. Mullenders, A.B. Houtsmuller, P.J. Verschure and R. van Driel. Heterochromatin protein 1 is recruited to various types of DNA damage. J. Cell Biol. 185:577-586
39. Dantuma, N.P., C. Heinen, D. Hoogstraten. The ubiquitin receptor Rad23: At the crossroads of nucleotide excision repair and proteasomal degradation. DNA Repair (Amst). 8:449-460
40. Salomons, F.A., V. Menéndez-Benito, C. Böttcher, B. McCray, J.P. Taylor and N.P. Dantuma. Selective accumulation of aggregation-prone proteins in response to proteotoxic stress. Mol. Cell. Biol. 29:1774-1785
41. Verhoef, L.G.G.C., C. Heinen, A. Selivanova, E. Halff, F.A. Salomons and N.P. Dantuma. Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates. FASEB J. 23:123-133
42. Cheroni, C., M. Marino, M. Tortarolo, V. Veglianse, S. De Biasi, E. Fontana, L. Vitellaro Zuccarello, C.J. Maynard, N.P. Dantuma and C. Bendotti. Functional alterations of the ubiquitin proteasome system in motor neurons of a mouse model of familial Amyotrophic Lateral Sclerosis. Hum. Mol. Genet. 18:82-96
43. Kalocsay M, Hiller NJ, Jentsch S. Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break. Mol Cel. 33:335-43
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