PR07 - 08.04.01: Professor Dieter H. Wolf was honored with the Prize for Basic Sciences of the Land Baden-Württemberg of Germany. In addition, he became a Corresponding member of the Heidelberg Academy of Sciences (»Add to Infobox)

Avila-Cariño Javier

Maria Masucci's Group

Prize for Basic Sciences of the Land Baden-Württemberg of Germany In June 2007 Prof. Dr. Dieter H. Wolf, University of Stuttgart, received the research prize for Basic Sciences of the Land Baden-Württemberg of Germany. This award is endowed with 100,000 €. Prof. Wolf received the prize for his pioneering work in the area of regulated protein degradation. It was Dieter Wolf’s group who, on genetic grounds, discovered the involvement of the proteasome, a large protein degrading machine, in ubiquitin linked, regulated protein degradation, a targeting mechanism for which later the Nobel Prize was given to Aaron Ciechanover, Avram Hershko and Irwin Rose. Somewhat later Dieter Wolf succeeded in a very surprising discovery: He could show that protein waste of the secretory pathway is discovered in the endoplasmic reticulum (ER) and retrograde transported back over the ER membrane barrier into the cytoplasm of the cell, where the components of the degradation machinery reside, which eliminate the protein waste. This research has huge implications for medicine. It lays the basis for the understanding of a variety of diseases as are neurodegenerative diseases like Parkinson, Alzheimer, etc. as well as the hereditary disease Cystic fibrosis. Dieter Wolf is an active member of the European network of excellence, RUBICON. For more details in German, follow the link: http://www.uni-stuttgart.de/ibc/aktuelles/ind ex_en.html Corresponding member of the Heidelberg Academy of Sciences In January 2008, Prof. Dr. Dieter H. Wolf, University of Stuttgart, was elected as a corresponding member of the Heidelberg Academy of Sciences.

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Avila-Cariño Javier (Scientific Manager / Maria Masucci's Group)