PR3 09.02.13: How cells handle broken chromosomes (»Add to Infobox)

Jentsch Stefan

Stefan Jentsch's Group

Scientists from the Max Planck Institute of Biochemistry discovered a novel cellular response towards persistent DNA damage: After being recognized and initially processed by the cellular machinery, the broken chromosome is extensively scanned for homology and the break itself is later tethered to the nuclear envelope. Thus the researchers uncovered a surprising feature of how DNA strand breaks can be handled. Their unexpected findings have important implications for the understanding of DNA repair mechanisms. (Molecular Cell 33, February 13th, 2009) For more information open the download file.

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Jentsch Stefan (Principal Investigator / Stefan Jentsch's Group)

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