LA8 - The importance of recycling in Alzheimer’s disease (»Add to Infobox)

Dantuma Nico, Associate Professor

Nico Dantuma's Group

Nico P. Dantuma and Laura Bott Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden The cells that compose our bodies are absolute masters in recycling. Old, wornout or damaged proteins are continuously being broken down to their building units which can then be used for the generation of new proteins. Perfect as it may seem, sometimes things can turn ugly. In a number of diseases that primarily concern the nervous system, “waste” proteins are not being properly handled. Instead of being recycled, faulty proteins accumulate over time and cause serious problems. Notorious examples of so‐called neurodegenerative disorders are Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. What happens in these disorders? Why are the proteins not destroyed and how do they intoxicate the cells? These and other important questions relating to protein destruction are a major focus in our research. In order to increase our understanding of the connection between protein recycling and devastating neurological diseases, we have developed tools that allow us to study protein turnover in cells and animals. Download the PDF file to learn how malfunction of waste processing is leading to Alzheimer’s disease.

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Dantuma Nico, Associate Professor (Principal Investigator / Nico Dantuma's Group)

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