Rosine Haguenauer-Tsapis (»Add to Infobox)

Principal Investigator Rosine Haguenauer-Tsapis's Group Academic: French National Center for Scientific Research (CNRS) Phone:  +33 1 57 27 80 52 Email:  haguenauer.rosineijm.univ-paris-diderot.fr

Rosine Haguenauer-Tsapis's Laboratory: Ubiquitin and Trafficking General description: We use yeast as a model system for studies on the secretory and endocytic pathway. Discovery of the role of ubiquitin and Rsp5p in the internalization step of endocytosis using a transporter as a model endocytic cargo. Our studies focused on the E3 Rsp5, and its functions in internalization and MVB sorting. We notably evidenced the Rsp5-dependent modification of endocytic and MVB cargoes by K63-linked ubiquitin chains. We also study the potential role of ubiquitin in the regulation of trafficking of plasma membrane transporters (ubiquitylation events in Golgi to vacuole trafficking instead of plasma membrane targeting). Additional subjects include studies on Golgi to vacuole trafficking (discovery of membrane-bound Vps proteins) and on endosome to plasma membrane recycling. We focused recently on the role of some DUBs and their partners in mitochondrial functions. Role in RUBICON: Principal investigator, and will thus coordinate the various subjects.

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