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Matthias Mann
General description:
Recent methodological advances in mass spectrometry-based quantitative proteomics pioneered by our laboratory offer a powerful opportunity to characterize different aspects of the Ub network on a large scale. Stable Isotope Labeling by Amino acids in Cell culture (SILAC) for instance allows us to measure differences in two proteomes quantitatively. In particular I try to find substrates of E3 ligases after different stimuli using the SILAC technique.
Furthermore I try to streamline the technology that enables us the identification of ubiquitination sites and isolation of ubiquitinated peptieds.
Role in RUBICON:
Collaborations with other Rubicon groups
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Research Projects
RUBICON Fellows
biochem.mpg.de