Andreas Marquardt, Post-doc (»Add to Infobox)

Martin Scheffner's Group Academic: University of Konstanz Phone:  +49-7531-883928 Fax:  +49-7531-883097 Email:  andreas.2.marquardtuni-konstanz.de

http://www.biologie.uni-konstanz.de/scheffner /index.html General description: Andreas is a chemist by training with a particular interest into protein analytics and mass spectrometry. Using a combination of RNA-interference-based approaches and mass spectrometry, he is involved in studies to determine and characterize interaction partners and substrates of the ubiquitin ligase E6-AP. Since loss of E6-AP function is responsible for the development of the Angelman Syndrome, these studies are expected to contribute to the elucidation of the pathophysiological mechanisms underlying this hereditary neurological disorder. In addition, Andreas is using synthetic chemistry to synthesize di-ubiquitin molecules with defined linkage (e.g. via lysine 63 or lysine 11 of ubiquitin), which should prove useful in the identification of proteins that interact with polyubiquitin chains in a linkage-specific manner and in the generation of "linkage-specific" anti-ubiquitin antibodies.