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C1a: 2010, October 4-7. ZOMES VI Conference, Safed Academic College, Safed, Israel
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The ZOMES meetings focus on the biology of the three “PCI” complexes, the proteasome, the COP9 signalosome, and eIF3, and also additional complexes, such as E3-ubiquitin ligases, which interact with and are regulated by the PCI complexes. The study of large protein complexes -"Zomes" - poses unique issues and difficulties, and the ZOMES meetings aim at providing a forum for discussing the connections between these complexes and central signaling pathways.
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The international meeting "Zomes VI" (http://www.weizmann.ac.il/conferences/ZOMESVI /) sponsored by RUBICON took place as an advanced research workshop of the Israel Science Foundation (ISF) in Safed, Israel between October 4-7. Zomes VI is part of an international series focusing on three large homologous protein complexes, the proteasome, the COP9 signalosome, and eIF3 (PCI complexes). A brief history of the Zomes series can be found at: http://ibis.tau.ac.il/twiki/bin/view/Plant_S/ ZOMEBase/ZomesMeetings.
Of the 117 participants attending the ZomesVI meeting, more than half were students and postdocs who received subsidized rates. Of the 52 speakers, 13 were women and of the total, 24 were invited and the rest chosen from abstracts. The speakers represented a range of countries: 22 from the EU, 9 from the USA, and 21 from Asia covering a broad range of topics from developmental processes regulated by Zomes complexes, to biochemical mechanisms, molecular structure using biophysical approaches and high throughput screens to detect novel substrates or interacting factors. In general: The ZOMES meetings focus on the biology of the three “PCI” complexes, the proteasome, the COP9 signalosome, and eIF3, as well as additional complexes, such as E3-ubiquitin ligases, which interact with, or are regulated by, the PCI complexes. Specific attention at Zomes VI went “beyond the three canonical PCI complexes” to explore interactions between the Zomes complexes and others cellular pathways.
The Meeting opened by two Nobel Laureates whose discoveries in identifying some of the key molecular factors established this field of research serving -to a large extent- to pave the way for subsequent Zomes researchers. Avraham Hershko (Technion) discussed the early discoveries of ubiquitin and proteasome and Ada Yonath (WI) detailed recent structural properties of the Ribosome and its inhibitors. Each of the next three days opened with an invited Keynote lecture followed by 3-4 lecture sessions of shorter talks. The Keynote speakers were (in order) Ning Wei (Yale) who described interactions of CSN subunits, Mark Hochtrsasser who detailed proteasome assembly and mode of action, and Nevan Krogan (UC) who illustrated the power of Systems Biology and high throughput screens to indentify new Zomes-related pathways and interactions. The remaining scientific talks were roughly organized into themes focusing on scientific approach or methodology, for example Structural analysis primarily of Zomes complexes but also of individual subunits or modifications (Michael Groll, Ed Morris, Ami Navon, David Fushman, Michal Sharon, Joel Hirsh), effects on cell-signaling and development (Ning Wei, Jeurgen Bernhagen, Gerhard Braus, Daniel Segal, Rosa Lozano-Duran, Lionel Pintard, Noriko Kato and many others), mechanism or mode of action (Tingting Yao, Dina Rave, Nurit Levanon, Cordula Enenkel, Keith Willison, Bernat Crossas, Yossi Shaul, March Hochtrsaser and Phil Coffino) and Systems Biology or interzome relations (Nevan Krogan, Rick Vierstra, Shay Ben Aroya, Eric Chang, Dieter Wolf). Two cozy poster sessions ended the days with casual yet lively discussions in the ancient underground halls of the Hotel venue. All students were expected to present a poster, thus 50 posters were on display. Poster sessions lasted way past midnight accompanied by drinks and light food.
One of the resolutions at the meeting was to establish an interactive community-based website to raise questions and coordinate key findings, nomenclature. A beta version of this site is up and running under “ZomeBase” (http://ibis.tau.ac.il/twiki/bin/view/Plant_S/ ZOMEBase/WebHome).
On Friday Oct 8th after the meeting, most Zomes participants joined an optional trip to the Galilee, including an up-hill down-hill hiking journey and archeological sites.
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