General description:
Pascal Genschik, is currently the Scientific Director of the Institut de Biologie Moléculaire des Plantes du CNRS. In the past, he was studying nucleotide and RNA metabolism in both animal and plant cells. His current research aims to understand the function of ubiquitin-dependent proteolysis in the control of the plant cell cycle and different phytohormonal signaling pathways. Among his achievements are the studies on plant mitotic cyclins and the functional characterization of different ubiquitin ligases in the model plant Arabidopsis thaliana (e.g., CUL1, CUL3, APC2 and Rbx1). Thus, his group unravelled the function SCF-mediated proteolysis in a phytohormone-signalling pathway (e.g., ethylene). Finally, in collaboration with researchers from the same Institute, he became interested by the function of putative viral encoded ubiquitin-ligase components.
Role in RUBICON:
The group will characterize at the structural and functional level a Polerovirus encoding F-box protein (P0) that act as a silencing suppressor. Moreover the group will functionally characterize novel components in the ubiquitin pathway in plants and identify post-translational modifications occurring on plant ubiquitin substrates.
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