Yinon Ben-Neriah's Group (»Add to Infobox)

General description: We are studying signal transduction pathways incorporating phosphorylation and ubiquitination, in particular the NF-kB and Wnt signaling pathways. Our aim is to understand the regulation of phosphorylation and the destruction machineries of b-catenin, NF-kB and IkBa, identify signaling molecules and their mechanisms of action. We then study the biological consequences of mutations in these pathways in specific animal models with relevance to human disease, particularly cancer, inflammation and immunity. Role in RUBICON: Study of b-catenin stability regulation at the Wnt signaling pathway Dissect the global cellular and organismic effects of distinct E3s involved in the Wnt pathway Study the basis for the stability of IkBa following TLR stimulation in polarized epithelial cells

MEMBERS (13/13)

Ben-Neriah Yinon (Principal Investigator / Yinon Ben-Neriah's Group)