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General description: The family of deubiquitinating enzymes (DUBs) comprises approximately 80 members and the list is growing since this field of research has focused plenty of attention on DUBs the last years. My work aims to gain a better understanding, on a molecular level, of the function of DUBs in various cellular signaling pathways. I use an DUB RNAi library, to identify enzymes that regulate cellular signal transduction pathways such as the Wnt-signaling pathway. My goal is to continue the search to gain a better understanding of the diverse functions of DUBs.
Role in RUBICON:
My role in RUBICON is to explore the field of deubiquitinating enzymes (DUBs) and work on their functional characterization. I and supervise, some of the ongoing DUB related projects in our laboratory. I will also guide some of the newcomers and initiate novel projects within this field of research.
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