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General description:
To exploit and translate the scientific data into application we are setting up screens to find small molecular drugs that can be used to fight cachexia in humans. For this purpose we also develop cachexia mouse models. This is a collaborative project with DDF BV.
Role in RUBICON:
The aim of my project is to discover compounds which improve the growth hormone (GH) sensitivity in cancer induced cachexia, a syndrome characterized by anorexia, body weight loss, loss of adipose tissue and skeletal muscle. Stimulation of an anabolic pathway like the GH insulin-like growth factor-1 (IGF-1) axis could be a therapy to prevent or reverse body weight loss. Our approach is to increase the sensitivity for GH by reducing endocytosis of the growth hormone receptor (GHR). Three cell-based assays are used to screen for small compounds, which disturb the endocytosis of the GHR. Currently, an in vitro assay to screen for compounds which prevent the binding between the GHR and an E3 ligase is in a developmental stage.
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Ger Strous's Group
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Our Research
Research Projects
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