Simona Polo (»Add to Infobox)

Principal Investigator Simona Polo's group Academic: IFOM- FIRC Institute of Molecular Oncology, Milan Phone:  +39 2 574303242 Email:  simona.poloifom-ieo-campus.it

General description: The monoubiquitin (monoUb)-network is emerging as a major regulator of protein function beyond its well-established role in protein degradation. While initial observations in various labs project a physiological relevance of monoubiquitination comparable to that of phosphorylation, the characterization of the system has only just begun. We are trying to integrate a wide proteomic approach to monoUb as a signaling device with high-resolution studies of how monoUb can modulate the function of endocytic/signaling proteins. Presently three major levels of study are being pursued in the lab: 1.  Elucidating the monoUb proteome. 2.  Dissecting the role of monoubiquitination in endocytosis 3.  Elucidating the molecular mechanisms of coupled monoubiquitination Role in RUBICON: Supervision of work on the monoubiquitin proteome

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