C3c: 2008, June 2-6, Functions of Ubiquitin and Ubiquitin-related Protein-Protein Modifications in Cell Biology, Lauterbad, Germany (»Add to Infobox)

Wolf Dieter H.

Dieter H. Wolf's Group

Joint course of the Marie-Curie progAramme UbiRegulators and Rubicon: Functions of Ubiquitin and Ubiquitin-related Protein-Protein Modifications in Cell Biology

Between June 2 and June 6 the teaching course on ″Functions of Ubiquitin and Ubiquitin-Related Protein-Protein Modifications in Cell Biology″, organized by Dieter H. Wolf from the University of Stuttgart for students of the Marie-Curie program ″UbiRegulators″ and the Network of Excellence ″RUBICON″ was taking place. It was organized in the ″Hotel Zollernblick″ in Lauterbad near Freudenstadt in the Black Forest. This University-owned hotel was chosen to allow a maximum of interaction between the teachers and the students, also during the free time. Seventeen students took part in the course. A highly potent group of teachers from the US and Europe had been assembled to get an up to date overview of the fields covered as well as insight into the newest developments. The scientific fields and the speakers were: Hidde Ploegh from the Massachusetts Institute of Technology in Cambridge, USA, talked about ″Mechanisms, Biology and Inhibitors of De-ubiquitinating Enzymes″. He also talked about his early work on ER-associated degradation of misfolded secretory proteins and initiated a very lively discussion on his lipid droplet hypothesis on retrograde transport of misfolded proteins from the ER into the cytoplasm. Dan Finley from Harvard Medical School in Boston, USA, gave very good insight into ″Regulation at the Proteasome″. Scott Emr from Cornell University, Ithaca, New York, gave a comprehensive overview of the ESCRT pathway, detailing of how proteins enter the lysosome/vacuole via multiversicular bodies. Jürgen Dohmen from the University of Cologne gave insight about the new finding of ″SUMO-specific Ubiquitin Ligases″. Helle Ulrich from the Medical Research Council in London explained the connection between ″SUMO, Ubiquitin and DNA repair″. Fulvio Reggiori from the University of Utrecht in the Netherlands provided the students with a detailed overview of the self eating of cells ″Autophagocytosis″. Finally Dieter H. Wolf from the University of Stuttgart and Thomas Sommer from the Max-Delbrück-Center in Berlin told their stories of an - at the time of discovery completely unexpected mechanism - ″Protein Quality Control and Degradation of Misfolded Proteins of the Endoplasmic Reticulum″. Each lecture was followed by intensive discussions and the presentation of papers of seminal work on the respective topic by the students. The students were especially interested in the face-to-face contact with those ″famous″ professors, who are expected to be not reachable in conferences for students. In the relaxed atmosphere of the lounge it was easy to make contact to them and talk about basic problems and topics students have. Both parties appreciated very much the setting of the course and the intensive exchange between each other. The local flavour of the course setting in the Black Forest was demonstrated by the food and an original ″Black Forest Cherry tart″.

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Wolf Dieter H. (Principal Investigator / Dieter H. Wolf's Group)

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