General description: The monoubiquitin (monoUb)-network is emerging as a major regulator of protein function beyond its well-established role in protein degradation. While initial observations in various labs project a physiological relevance of monoubiquitination comparable to that of phosphorylation, the characterization of the system has only just begun. We are trying to integrate a wide proteomic approach to monoUb as a signaling device with high-resolution studies of how monoUb can modulate the function of endocytic/signaling proteins. Presently three major levels of study are being pursued in the lab:
1. Elucidating the monoUb proteome.
2. Dissecting the role of monoubiquitination in endocytosis
3. Elucidating the molecular mechanisms of coupled monoubiquitination
Role in RUBICON: The aim of the group is to understand the molecular details of monoubiquitination and deubiquitination events and the way these events are regulated by the signaling pathways.