Dieter H. Wolf (»Add to Infobox)

Principal Investigator Dieter H. Wolf's Group Academic: University of Stuttgart Phone:  +49 711 685 4390 Email:  dieter.wolfibc.uni-stuttgart.de

General description: Research in the frame of RUBICON of the PI centers in the question of how malfolded proteins of the endoplasmic reticulum and of the cytoplasm are selectively recognised and how they are finally delivered to the ubiquitin proteasome system for degradation. Gene products involved in these processes are idientified on the basis of genomic screens and pulldown experiments. Special attention will also be given to the retrograde transport of malfolded ER-proteins across the ER membrane back into the cytoplasm (retrotranslocation) for delivery to the proteasome. Figure The similarities and the dissimilarities of the recognition and delivery process to the proteasome of malfolded ER and cytoplasmic proteins will be an additional focus of the research. Link: http://www.uni-stuttgart.de/ibc/ Role in RUBICON: Applicants for posdoctoral positions should have a strong education in biochemistry and molecular biology. Experience with yeast and/or the ubiquitin-proteasome system would be advantagous but is not required. Applications (CV, publication list, contact details of two referees) should be submitted to Prof. Dr. Dieter H. Wolf, Institut für Biochemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany; e-mail: dieter.wolf@ibc.uni-stuttgart.de

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