Stefan Jentsch (»Add to Infobox)

Principal Investigator Stefan Jentsch's Group Academic: Max Planck Society for the Advancement of Science Phone:  +49 89 8578 3000 Fax:  +49 89 8578 3011 Email:  jentschbiochem.mpg.de

Stefan Jentsch General description: Our laboratory has a long-standing interest in protein modification by ubiquitin and ubiquitin-like proteins. Our research focuses primarily on functional aspects. We identify from yeast and mammalian cells the enzymatic components of these systems, clone the corresponding genes, and study their functions in vitro and in vivo. We showed by genetic analysis that enzymes of the ubiquitin pathway mediate degradation of abnormal proteins, stress tolerance, DNA repair, and cell cycle progression. We discovered that ubiquitylated proteins are degraded by the proteasome in vivo and found that ER-associated protein degradation (ERAD) involves the cytosolic ubiquitin/proteasome system. We also discovered the highly conserved ubiquitin-like modifier Rub1 (NEDD8) and described its complete conjugation system. More recently, we became particularly interested in the non-proteolytic functions of ubiquitylation and in the function of the ubiquitin-like modifier SUMO. For more details visit: http://www.biochem.mpg.de/jentsch/Jentsch.htm l Role in RUBICON: Coordinator for WP "Functions"

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